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Showing posts from July, 2018

Tet2 Induces Bone Cell Differentiation by Interacting with Runx1 and Regulates Genomic 5-Hydroxymethylcytosine (5hmC)

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Ten-Eleven Translocation two (TET2) is one amongst the foremost often mutated genes in adult myeloid malignancies, together with myelodysplastic syndrome (MDS), myeloproliferative tumor (MPN), chronic myelomonocytic leukaemia (CMML) , and acute chronic leukemia (AML) . TET2 is additionally found to be mutated in T–cell cancer (such as angioimmunoblastic T cancers) and B-cell non-Hodgkin lymphomas (such as diffuse massive B-cell lymphoma and mantle cell lymphoma) . Notably, TET2 mutations are rife in healthy aged people aged >70 years (∼5%) and are related to clonal haematopoiesis . Tet2 deficiency in mice leads to increased  haematogenic somaticcell (HSC) self-renewal. what is more, Tet2 loss skews the differentiation of haematogenic stem/progenitor cells (HSPCs) towards granulocytic/monocytic lineage, often leading to monocytosis and accumulation of monocytes/macrophages in bone marrow (BM) and spleen of mice . Fusion of the monocyte-macrophages result in the formation of multinuc…

Microbial effect on food spoilage

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Food Spoilage is the process where food deteriorates and turns in to a form that are not edible to human. There are Various external forces are responsible for the spoilage of food and organisms that are capable of spoiling food. As this includes signs such as change in the appearance colour and texture of the food. The more it is spoiled the more it changes in unpleasant odour and undesirable taste. In general food starts decomposing and spoils from the time of harvest due to the attack of microorganism and other enzymes. These include bacteria, yeast, moisture, temperature, old and other chemical reaction. Food waste acts as an important component of municipal solid waste. When bacteria break down the food, the acid and other waste product involves in the process as this can be responsible for spoilage of food. Though this bacterium may or may not be harmful this act upon the food products and produces unpleasant taste and sometimes a harmful effect on human. Bacteria such as Enter…

Researchers Analyse Biomarkers for Fat Risk in Women

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An impaired ability to interrupt down fats is related to later weight gain and metabolic disorders in women, according to a study revealed nowadays in Cell Metabolism. Researchers at the Karolinska Institute found that low levels of an organic chemistry method referred to as hormone-stimulated lipolysis were connected to augmented weight and complications equivalent to kind a pair of polygenic disease thirteen years later, giving the chance of a diagnostic assay for fat risk similarly as improved interventions. This data may be utilized by clinicians to see who would benefit the foremost from intense life-style interventions corresponding to physical activity, which reinforces hormone-stimulated lipolysis and will so prevent fat accumulation and metabolic disturbances Ryden and his colleagues collected fat biopsies from eighty nine women, and followed up once a mean of thirteen years. The team found that, compared with women who went on to take care of a stable weight over that amoun…

Parkinson’s disease: Symptoms, Effects and Research

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Parkinson's disease that affects the central nervous system is known as the is a degenerative disorder that causes condition such as movement disorders. This causes as nerve cells or neurons in brain become impaired or die. Although this causes loss of neurons when the brain cells fail to produce a chemical known as dopamine as this are responsible for chemical messenger. This could be identified with the movement in the tremor, stiffness in the limbs or the trunk of the body or with the impaired balance. This are found to be in the case of hereditary and can be traced to specific genetic mutations as sometimes genetic along with environmental factor that trigger the disease. Researches has found that several genetic mutations that are associated with this disease such as alpha-synuclein gene, DJ-1, PINK1 and LRRK2 as discovering these genes could help in identifying the new way of treatment of disease. There are various primary and secondary symptoms that helps in the identifica…